Nuclear liquid-gas phase transition and supernovae evolution

It is shown that the large density fluctuations appearing at the onset of the first order nuclear liquid-gas phase transition can play an important role in the supernovae evolution. Due to these fluctuations, the neutrino gas may be trapped inside a thin layer of matter near the proto-neutron star surface. The resulting increase of pressure may induce strong particle ejection a few hundred milliseconds after the bounce of the collapse, contributing to the revival of the shock wave. The Hartree-Fock+RPA scheme, with a finite-range nucleon-nucleon effective interaction, is employed to estimate the effects of the neutrino trapping due to the strong density fluctuations, and to discuss qualitatively the consequences of the suggested new scenario.Comment: version2 - precise that nuclear liquid-gas phase transition is 1st order and the unique instable mode is isoscala

Deep Chronnectome Learning via Full Bidirectional Long Short-Term Memory Networks for MCI Diagnosis

Brain functional connectivity (FC) extracted from resting-state fMRI (RS-fMRI) has become a popular approach for disease diagnosis, where discriminating subjects with mild cognitive impairment (MCI) from normal controls (NC) is still one of the most challenging problems. Dynamic functional connectivity (dFC), consisting of time-varying spatiotemporal dynamics, may characterize "chronnectome" diagnostic information for improving MCI classification. However, most of the current dFC studies are based on detecting discrete major brain status via spatial clustering, which ignores rich spatiotemporal dynamics contained in such chronnectome. We propose Deep Chronnectome Learning for exhaustively mining the comprehensive information, especially the hidden higher-level features, i.e., the dFC time series that may add critical diagnostic power for MCI classification. To this end, we devise a new Fully-connected Bidirectional Long Short-Term Memory Network (Full-BiLSTM) to effectively learn the periodic brain status changes using both past and future information for each brief time segment and then fuse them to form the final output. We have applied our method to a rigorously built large-scale multi-site database (i.e., with 164 data from NCs and 330 from MCIs, which can be further augmented by 25 folds). Our method outperforms other state-of-the-art approaches with an accuracy of 73.6% under solid cross-validations. We also made extensive comparisons among multiple variants of LSTM models. The results suggest high feasibility of our method with promising value also for other brain disorder diagnoses.Comment: The paper has been accepted by MICCAI201

Lowest Order Constrained Variational Calculation of the Polarized Nuclear Matter with the Modern AV18AV_{18} Potential

The lowest order constrained variational method is applied to calculate the polarized symmetrical nuclear matter properties with the modern $AV_{18}$ potential performing microscopic calculations. Results based on the consideration of magnetic properties show no sign of phase transition to a ferromagnetic phase.Comment: 19 pages, 6 figure

Polarized Neutron Matter: A Lowest Order Constrained Variational Approach

In this paper, we calculate some of the polarized neutron matter properties, using the lowest order constrained variational method with the $AV_{18}$ potential and employing a microscopic point of view. A comparison is also made between our results and those of other many-body techniques.Comment: 23 pages, 8 figure

Spin polarized neutron matter within the Dirac-Brueckner-Hartree-Fock approach

The relation between energy and density (known as the nuclear equation of state) plays a major role in a variety of nuclear and astrophysical systems. Spin and isospin asymmetries can have a dramatic impact on the equation of state and possibly alter its stability conditions. An example is the possible manifestation of ferromagnetic instabilities, which would indicate the existence, at a certain density, of a spin-polarized state with lower energy than the unpolarized one. This issue is being discussed extensively in the literature and the conclusions are presently very model dependent. We will report and discuss our recent progress in the study of spin-polarized neutron matter. The approach we take is microscopic and relativistic. The calculated neutron matter properties are derived from realistic nucleon-nucleon interactions. This makes it possible to understand the nature of the EOS properties in terms of specific features of the nuclear force model.Comment: 6 pages, 11 figures, revised/extended calculation

Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake

Indexación: Web of Science.Poly(amidoamine) dendrimers are the most recognized class of dendrimer. Amino-terminated (PAMAM-NH2) and hydroxyl-terminated (PAMAM-OH) dendrimers of generation 4 are widely used, since they are commercially available. Both have different properties, mainly based on their different overall charges at physiological pH. Currently, an important function of dendrimers as carriers of short single-stranded DNA has been applied. These molecules, known as antisense oligonucleotides (asODNs), are able to inhibit the expression of a target mRNA. Whereas PAMAM-NH2 dendrimers have shown to be able to transfect plasmid DNA, PAMAM-OH dendrimers have not shown the same successful results. However, little is known about their interaction with shorter and more flexible molecules such as asODNs. Due to several initiatives, the use of these neutral dendrimers as a scaffold to introduce other functional groups has been proposed. Because of its low cytotoxicity, it is relevant to understand the molecular phenomena involving these types of dendrimers. In this work, we studied the behavior of an antisense oligonucleotide in presence of both types of dendrimers using molecular dynamics simulations, in order to elucidate if they are able to form stable complexes. In this manner, we demonstrated at atomic level that PAMAM-NH2, unlike PAMAM-OH, could form a well-compacted complex with asODN, albeit PAMAM-OH can also establish stable interactions with the oligonucleotide. The biological activity of asODN in complex with PAMAM-NH2 dendrimer was also shown. Finally, we revealed that in contact with PAMAM-OH, asODN remains outside the cells as TIRF microscopy results showed, due to its poor interaction with this dendrimer and cell membranes.http://nanoscalereslett.springeropen.com/articles/10.1186/s11671-016-1260-

Combining brain-computer interfaces and assistive technologies: state-of-the-art and challenges

In recent years, new research has brought the field of EEG-based Brain-Computer Interfacing (BCI) out of its infancy and into a phase of relative maturity through many demonstrated prototypes such as brain-controlled wheelchairs, keyboards, and computer games. With this proof-of-concept phase in the past, the time is now ripe to focus on the development of practical BCI technologies that can be brought out of the lab and into real-world applications. In particular, we focus on the prospect of improving the lives of countless disabled individuals through a combination of BCI technology with existing assistive technologies (AT). In pursuit of more practical BCIs for use outside of the lab, in this paper, we identify four application areas where disabled individuals could greatly benefit from advancements in BCI technology, namely,“Communication and Control”, “Motor Substitution”, “Entertainment”, and “Motor Recovery”. We review the current state of the art and possible future developments, while discussing the main research issues in these four areas. In particular, we expect the most progress in the development of technologies such as hybrid BCI architectures, user-machine adaptation algorithms, the exploitation of users’ mental states for BCI reliability and confidence measures, the incorporation of principles in human-computer interaction (HCI) to improve BCI usability, and the development of novel BCI technology including better EEG devices

Memoria de la intervención arqueológica en la estructura tumular de Sotoaldea (Mañeru, Navarra)

Se presenta el balance del resultado de la excavación arqueológica, por vía de urgencia, en una estructura megalítica descubierta sobre terraza fluvial, en la red hidrográfica del Ebro medio. Tanto la datación relativa como la absoluta sitúan su momento de uso en el Calcolítico precampaniforme

Joule heating and the thermal evolution of old neutron stars

We consider Joule heating caused by dissipation of the magnetic field in the neutron star crust. This mechanism may be efficient in maintaining a relatively high surface temperature in very old neutron stars. Calculations of the thermal evolution show that, at the late evolutionary stage ($t \geq 10$ Myr), the luminosity of the neutron star is approximately equal to the energy released due to the field dissipation and is practically independent of the atmosphere models. At this stage, the surface temperature can be of the order of $3 \times 10^{4} - 10^{5}$K. Joule heating can maintain this high temperature during extremely long time ($\geq 100$ Myr), comparable with the decay time of the magnetic field.Comment: 13 pages (5 figures in the text). Accepted for publication in The Astrophysical Journa